This immune cell in blood may up severe Covid risk

In the study, published in the Journal of Clinical Investigation, the team researched one type of immune cell, monocytic myeloid-derived suppressor cells, or M-MDSC, and their potential role in Covid-19.

"Our results help increase the understanding of what causes severe Covid-19 and is an important piece of the puzzle in understanding the connection between the early, innate immune system, which includes M-MDSC, and the later, adaptive immune system, which includes T cells," said researcher Anna Smed Sorensen from Karolinska Institutet.

T cells are part of the immune system and play an important part in the body's protection against viral infections such as Covid-19. M-MDSCs have been shown to increase in other inflammatory conditions, and their suppressive effect on T cell activity has been established.

The role of M-MDSC in respiratory infections, however, is largely unknown. Since low levels of T cells are a hallmark of Covid-19, it is of interest to understand the role of M-MDSCs in this disease.

The study consisted of 147 patients with mild to fatal Covid-19 who were sampled repeatedly from blood and the respiratory tract. These were then compared with patients with influenza and healthy individuals.

The results showed that patients with severe Covid-19 have significantly elevated levels of M-MDSCs in blood compared with milder cases and healthy individuals.

Covid-19 patients had fewer T cells in blood than healthy subjects, and they showed signs of impaired function.

The analysis also showed that the levels of M-MDSCs early in the course of disease seemed to reflect subsequent disease severity.

"There is also a strong clinical connection, as you could potentially use the results to find new biomarkers for severe illness," Sorensen added.