WHO moves to update COVID-19 guidance after 'great news' in drug study

Trial results announced on Tuesday by researchers in Britain showed dexamethasone, used since the 1960s to reduce inflammation in diseases such as arthritis, cut death rates by around a third among the most severely ill COVID-19 patients admitted to hospital.

Britain has increased the amount of dexamethasone it has in stock and on order to 240,000 doses, health minister Matt Hancock said.

But some doctors were cautious, citing possible side effects and asking to see more data.

The WHO’s clinical guidance for treating patients infected with the new coronavirus is aimed at doctors and other medical professionals and seeks to use the latest data to inform clinicians on how best to tackle all phases of the disease, from screening to discharge.

Although the dexamethasone study’s results are preliminary, the researchers behind the project said it suggests the drug should immediately become standard care in severely stricken patients.

For patients on ventilators, the treatment was shown to reduce mortality by about one third, and for patients requiring only oxygen, mortality was cut by about one fifth, according to preliminary findings shared with WHO.

The benefit was only seen in patients seriously ill with COVID-19 and was not observed in patients with milder disease.

The positive news comes as coronavirus infections accelerated in some places including the United States and as Beijing cancelled scores of flights to help contain a fresh outbreak in China’s capital.

“This is the first treatment to be shown to reduce mortality in patients with COVID-19 requiring oxygen or ventilator support,” WHO Director-General Tedros Adhanom Ghebreyesus said in a statement late on Tuesday. The agency said it was looking forward to the full data analysis of the study in coming days.

“WHO will coordinate a meta-analysis to increase our overall understanding of this intervention. WHO clinical guidance will be updated to reflect how and when the drug should be used in COVID-19,” the agency added.

South Korea’s top health official cautioned about the use of the drug for COVID-19 patients due to potential side effects.

“Some experts have warned of the drug not only reducing the inflammatory response in patients, but also the immune system and may trigger side effects,” said Jeong Eun-kyeong, head of Korea Centers for Disease Control and Prevention.

“We have been burned before, not just during the coronavirus pandemic but even pre-COVID, with exciting results that when we have access to the data are not as convincing,” said Dr. Kathryn Hibbert, director of the medical intensive care unit at Harvard’s Massachusetts General Hospital.